Mat Ryan will be looking to extend a stunning run of form for Brighton this weekend, while fellow Caltex Socceroos star Tom Rogic has a top-of-the-table clash to focus on after reaching his recent milestone.
There's also a need for an immediate response for Trent Sainsbury and Aziz Behich's PSV and Rosenborg's Alex Gersbach are on the brink of claiming a league title.
Read on to find out when they're in action, with all times in AEDT!
England: Ryan looks to extend clean sheet streak
Mat Ryan will be looking to rack up a fourth successive English Premier League clean sheet when his Brighton side visit Everton at 2am on Sunday.
The Caltex Socceroos No.1 completed an October clean sweep of clean sheets as the Seagulls racked up their third successive 1-0 win, beating Wolves last time out.
Ryan might, however, be hoping for a quieter day at the office this time after making 13 saves during his last two outings.
Meanwhile, Aaron Mooy is embroiled in an early season relegation six-pointer as his winless Huddersfield side look to climb off the foot of the table when they host Fulham.
The Cottagers have performed little better and sit third-from-bottom ahead of their John Smith's Stadium clash at 7am on Tuesday morning.
In the Championship, Bailey Wright’s Bristol City head to Reading, Massimo Luongo's Queens Park Rangers visit Blackburn and Jackson Irvine’s Hull City host West Brom, all at 2am on Sunday.
Scotland: Rogic's Hoops hunting Hearts
Tom Rogic enjoyed a near-perfect 150th appearance for Celtic as he opened the scoring in a midweek 5-0 thumping of Dundee United.
However, it was tainted by the sight of compatriot Daniel Arzani being stretchered off with a knee injury on his debut for the club.
The Hoops have a crucial clash at 2am on Sunday as they host Scottish Premiership early front-runners Hearts, with Celtic having the chance to reduce their lead to a single point with victory.
With Mark Milligan, Jamie Maclaren and Martin Boyle in their ranks, Hibernian are perched in the chasing pack and host St Johnstone at the same time.
Netherlands: Dutch courage required after cup upset
Trent Sainsbury and Aziz Behich will be looking to ensure PSV’s shock KNVB Cup defeat to second-tier side RKC Waalwijk does not have an knock on effect on their Eredivisie campaign.
They host Vitesse at 4am on Sunday looking to protect a five-point lead at the top of the table.
Denis Genreau enjoyed contrasting fortunes to his compatriots, setting up the first two goals of PEC Zwolle’s 5-2 victory at fellow Eredivisie outfit De Graafschap.
The Australia Under-20 starlet will now be looking to fire his side into the top half of table when they visit Fortuna Sittard at 12.30am on Monday.
Rest of Europe: Gersbach on the brink of title glory
Alex Gersbach’s Rosenborg host Odd Stromsgodset at 4am on Monday with the Eliteserien title in their sights, sitting five points clear with just three games remaining.
In Germany, Mathew Leckie will be hopeful of being involved in Hertha Berlin’s clash with Red Bull Leipzig that kicks off at 4.30am on Sunday.
Leckie missed out on Hertha’s 2-2 draw at Bundesliga leaders Borussia Dortmund last week.
In the German second tier, Robbie Kruse’s VfL Bochum visit Greuther Furth at 4.30am on Saturday.
In Denmark, Awer Mabil’s Midtjylland visit Esbjerg at 4.30am on Monday, while Mustafa Amini's Aarhus GF are in Danish Superliga action as they host Randers at 2.30am on Monday.
Over in Belgium, Danny Vukovic’s league leading Genk side have a top-of-the-table clash with second-placed Club Brugge at 4am on Sunday.
Apostolos Giannou’s AEK Larnaca will be hoping to close the gap on early Cypriot First Division front runners AEL at the same time, with both sides protecting unbeaten starts to the season.
Over in Serbia, Milos Degenek’s runaway leaders Red Star Belgrade have a trip to Proteler Novai Sad at 1am on Sunday, while Tomi Juric’s Luzern host FC Zurich at 2am on Sunday.
Asia: Jones looks to protect narrow lead
Andrew Nabbout, Mitchell Duke and Mitchell Langerak are all in J-League action on Saturday.
Duke’s Shimizu S-Pulse side visit Shonan Bellmare at 4pm on Saturday, while Langerak’s Nagoya Grampus host Vissel Kobe at the same time.
Nagoya sit just one point clear of the relegation zone.
Just two hours later, Nabbout’s Urawa Red Diamonds play host to Gamba Osaka.
Then on Sunday, Brad Jones’ Al-Nassr will look to protect their single-point Saudi Pro League lead when they host third-placed Al Ahli at 1.55am.
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