Ange Postecoglou’s side take on Syria in a must-win two-leg playoff, with the first match away on October 5.
The return leg will then take place at Stadium Australia five days later, with a big home crowd vital to help get the Caltex Socceroos over the line.
“Stadium Australia has been a successful venue for us in the past,” Football Federation Australia CEO David Gallop said.
“We’ve had some very special results there and I’m sure this will be another one.”
The winner of the Asian Play-off will then face the fourth placed team from the CONCACAF region in a two-legged home and away series in November for a place at the 2018 FIFA World Cup in Russia.
Which means the Caltex Socceroos will take a massive step on the Road to Russia with victory at the same venue that hosted the historic qualification win over Uruguay in 2005.